The settings in the lighting tab are the key to solve your issue. Try to increase the GI samples or shadow quality and see what happens with a region render. You can try the custom control feature too, that has a "denoising" filter built in. How to control the settings and what they do is very well described in the KS manual.
If nothing helps, try to denoise your image with external denoisers. Like...
"D-NOISE" for Blender (free). It can handle external images using the OptiX AI-denoiser from NVIDIA (Nvidia GPU required).
... or
"AI Clear" ($59.99)
Or you can compile and use the
"Intel Open Image Denoise" 
... This one is also open source (free), works well on low samples images, but you need some programming skills and it's not as convenient as AI Clear or D-NOISE. There is a Blender branch on github that includes this denoiser (
https://developer.blender.org/D4304), but again - you would need to compile on your own.
Hope some of the information is helpful.
Cheers
Eugen